Harrison's Principles of Internal Medicine, 19th Edition, 2015, (Vol.1 & Vol.2), Auhors: Dennis Kasper, Joseph Loscalzo, Anthony Fauci, J. Jameson, Stephen Hauser, Dan Longo, ISBN: 9780071802154, Publisher: McGraw-Hill Education, [Hardcover] / English

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Harrison's Principles of Internal Medicine, 19th Edition, 2015, (Vol.1 & Vol.2), Auhors: Dennis Kasper, Joseph Loscalzo, Anthony Fauci, J. Jameson, Stephen Hauser, Dan Longo, ISBN: 9780071802154, Publisher: McGraw-Hill Education, [Hardcover] / English


Product Details


Series: Harrison's Principles of Internal Medicine

Hardcover: 3000 pages

Publisher: McGraw-Hill Education / Medical; 19 edition (April 8, 2015)

Language: English

ISBN-10: 0071802150

ISBN-13: 978-0071802154

Product Dimensions: 8.7 x 3.6 x 11.1 inches

Shipping Weight: 13.6 pounds


Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison's Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the new 19th edition of Harrison's provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods.


Here are just a few of the outstanding features of the new Nineteenth Edition:


  • Presented in two volumes: Volume 1 is devoted to foundational principles, cardinal manifestations of disease and approach to differential diagnosis; Volume 2 covers disease pathogenesis and treatment
  • NEW chapters on important topics such as Men's Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more
  • Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more.
  • Increased number of the popular Harrison's clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever
  • Access to outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, and more

Supporting the renowned coverage are supplemental resources that reflect and assist modern medical practice: more than 1,000 full-color photographs to aid visual recognition skills, hundreds of state-of-the-art radiographs, from plain film to 3D CT to PET Scans; beautiful illustrations that bring applied anatomy and processes to life; the renowned Harrison's patient-care algorithms, essential summary tables, and practical demonstrative videos. In addition, the book's several digital atlases highlight noninvasive imaging, percutaneous revascularization, gastrointestinal endoscopy, diagnosis and management of vasculitis, and numerous other issues commonly encountered in clinical practice.


Acclaim for Harrison's
"Covering nearly every possible topic in the field of medicine, the book begins with a phenomenal overview of clinical medicine, discussing important topics such as global medicine, decision-making in clinical practice, the concepts of disease screening and prevention, as well as the importance of medical disorders in specific groups (e.g. women, surgical patients, end of life). The extensive chapters that follow focus on a symptom-based presentation of disease and then illness organized by organ system. Numerous tables, graphs, and figures add further clarity to the text. The accompanying DVD includes extensive video and image collections of pathology, histology, procedures, additional lectures, and radiology...
...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. It is organized in a way that makes reading from beginning to end a logical journey, yet each chapter can stand alone as a quick reference on a particular topic. "


Table of Contents


Part 1 General Considerations in Clinical Medicine


Part 2 Cardinal Manifestations and Presentation of Diseases 


Section 1 Pain

Section 2 Alterations in Body Temperature

Section 3 Nervous System Dysfunction

Section 4 Disorders of Eyes, Ears, Nose, and Throat

Section 5 Alterations in Circulatory and Respiratory Functions

Section 6 Alterations in Gastrointestinal Function

Section 7 Alterations in Renal and Urinary Tract Function

Section 8 Alterations in Sexual Function and Reproduction

Section 9 Alterations in the Skin

Section 10 Hematologic Alterations


Part 3 Genes, the Environment, and Disease


Part 4 Regenerative Medicine


Part 5 Aging


Part 6 Nutrition and Weight Loss


Part 7 Oncology and Hematology


Section 1 Neoplastic Disorders

Section 2 Hematopoietic Disorders

Section 3 Disorders of Hemostasis


Part 8 Infectious Diseases

Section 1 Basic Considerations in Infectious Diseases

Section 2 Clinical Syndromes: Community-Acquired Infections

Section 3 Clinical Syndromes: Health Care–associated Infections

Section 4 Approach to Therapy for Bacterial Diseases

Section 5 Diseases Caused By Gram-Positive Bacteria

Section 6 Diseases Caused By Gram-negative Bacteria

Section 7 Miscellaneous Bacterial Infections

Section 8 Mycobacterial Diseases

Section 9 Spirochetal Diseases

Section 10 Diseases Caused By Rickettsiae, Mycoplasmas, and Chlamydiae

Section 11 Viral Diseases: General Considerations

Section 12 Infections Due to DNA Viruses

Section 13 Infections Due to DNA and RNA Respiratory Viruses

Section 14 Infections Due to Human Immunodeficiency Virus and other Human Retroviruses

Section 15 Infections Due to RNA Viruses

Section 16 Fungal Infections

Section 17 Protozoal and Helminthic Infections: General Considerations

Section 18 Protozoal Infections

Section 19 Helminthic Infections


Part 9 Terrorism and Clinical Medicine


Part 10 Disorders of the Cardiovascular System


Section 1 Introduction to CardiovasCular Disorders

Section 2 Diagnosis of Cardiovascular Disorders

Section 3 Disorders of Rhythm

Section 4 Disorders of the Heart

Section 5 Coronary and Peripheral Vascular Disease


Part 11 Disorders of the Respiratory System


Section 1 Diagnosis of Respiratory Disorders

Section 2 Diseases of the Respiratory System


Part 12 Critical Care Medicine 


Section 1 Respiratory Critical Care

Section 2 Shock and Cardiac Arrest

Section 3 Neurologic Critical Care

Section 4 Oncologic Emergencies


Part 13 Disorders of the Kidney and Urinary Tract


Part 14 Disorders of the Gastrointestinal System 


Section 1 Disorders of the Alimentary Tract

Section 2 Liver and Biliary Tract Disease

Section 3 Disorders of the Pancreas


Part 15 Immune-Mediated, inflammatory, and Rheumatology Disorders


Section 1 The Immune System in Health and Disease

Section 2 Disorders of Immune-Mediated Injury

Section 3 Disorders of the Joints and Adjacent Tissues


Part 16 Endocrinology and Metabolism


Section 1 Endocrinology

Section 2 Reproductive Endocrinology

Section 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome

Section 4 Disorders of Bone and Mineral Metabolism

Section 5 Disorders of Intermediary Metabolism


Part 17 Neurologic Disorders


Section 1 Diagnosis of Neurologic Disorders

Section 2 Diseases of the Central Nervous System

Section 3 Nerve and Muscle Disorders

Section 4 Chronic Fatigue Syndrome

Section 5 Psychiatric and Addiction Disorders


Part 18 Poisoning Drug Overdose, and Envenomation


Part 19 Disorders Associated with Environmental Exposures


Author comments


Dennis Kasper, MD is Professor of Medicine at Harvard and a leading researcher of the health and disease implications related to host-microbe interactions and the human microbiome.
Anthony Fauci, MD is Director of the National Institutes for Allergy and Infectious Diseases, and recipient of the Lasker Prize for Medicine. He is a leading authority in HIV and AIDS, immunology, and management of Ebola Virus Disease.
Dan Longo, MD is Deputy Editor, New England Journal of Medicine and Professor of Medicine, Brigham and Women's Hospital/Harvard Medical School. Dr. Longo is a highly regarded cancer specialist.
Stephen Hauser MD is Robert A. Fishman Distinguished Professor and Chair, Department of Neurology, UCSF School of Medicine. He is a leading authority on multiple sclerosis.
J. Larry Jameson, MD, PhD is Robert G. Dunlop Professor of Medicine, Dean, University of Pennsylvania School of Medicine, and Executive Vice President, University of Pennsylvania Health System.
Joseph Loscalzo MD, PhD is Hersey Professor of the Theory and Practice of Medicine, Harvard Medicine School and a leading authority in many aspects of cardiovascular medicine.






Main description

The landmark guide to internal medicine--updated and streamlined for today's students and clinicians


A Doody's Core Title for 2015.



The Editors are pleased to present the 19th edition of Harrison’s Principles of Internal Medicine. Since the first edition was published 65 years ago, virtually every area of medicine and medical education has evolved remarkably, and many new fields have emerged. 

While retaining the founding goals of Harrison’s, this edition has been modified extensively in light of the varied needs of the book’s readers and the diverse methods and formats by which information is now acquired and applied. The focus of medical education worldwide is shifting from the classic structure/function/disease approach to an integrated, often case-based approach in which basic and population sciences are specifically linked to the practical diagnosis and management of disease. Many of the updates and changes described here have been undertaken with the modern educational and clinical environments in mind. 

This new edition offers a thoroughly updated presentation of the classic pathophysiologic basis of clinical medicine and details the cutting-edge methods and tools that are now available for the assessment of symptoms and the effective management of diseases in the modern patient-care environment. The text is supplemented by germane new photographs, radiographs, illustrations, atlases, patient-care algorithms, tables, and practical demonstrative videos. 

In the interest of producing the most practical format possible for the 19th edition, a new system of referencing has been used. Detailed bibliographic listings, with summaries of articles’ relevance to practice, appear in the online edition, replacing the general and limited collection of Suggested Readings that appeared in the prior print editions. 

The 19th edition of Harrison’s is designed for accessibility and flexibility. The print textbook is available in two volumes. Volume 1 focuses on the foundations of medicine and the understanding and assessment of cardinal disease manifestations; Volume 2 focuses on specific diseases, by system. This functional division will be helpful to students who are mastering the basis of clinical medicine and to clinicians who are more focused on gaining an advanced understanding of mechanisms and patient care in specific diseases. In terms of digital media, Harrison’s is now available as an eBook on multiple platforms, as an enhanced “app” developed especially for tablet and smartphone devices that offer high-definition resolution of multimedia content and interactive features, and as an updated online edition. All of these options provide access to our numerous e-chapters as well as to videos and atlases. Additional resources include the Harrison’s Self-Assessment and Board Review, a useful study guide based on information in the 19th edition, and the Harrison’s Manual of Medicine, a pocket version of Harrison’s Principles of Internal Medicine. A new Harrison’s collection of case vignettes emphasizing differential diagnostic considerations in the assessment of cardinal manifestations will also be available. 

Advances in medical science have been spectacular since Harrison’s was first published in 1949. At that time, peptic ulcer disease was thought to be caused by stress, nearly every tumor that was not resected resulted in death, rheumatic heart disease was widely prevalent, and hepatitis B and HIV infection were unknown. In the intervening years, both the infectious cause of and the cure for peptic ulcer disease were identified; advances in diagnosis and treatment made it possible to cure two-thirds of cancers; rheumatic heart disease virtually disappeared; atherosclerotic coronary artery disease waxed and then—at least in part through management of modifiable risk factors—began to wane; hepatitis B and its consequences, cirrhosis and hepatocellular carcinoma, became preventable by a vaccine; and HIV, first viewed as a uniformly fatal worldwide scourge, became a treatable chronic disease. Notably, emerging and reemerging diseases have presented significant challenges to medical research and practice, while a new understanding of systems-wide concepts such as the microbiome offers exciting new possibilities for understanding and managing health and disease in ways never before possible. 

Of particular note in this 19th edition are critical updates in the classic chapter on HIV/AIDS, which offers both a clinically pragmatic focus and a comprehensive and analytical approach to pathogenesis. The updates cover the latest treatment protocols and address the issue of combination prevention modalities, making the chapter the most up-to-date and comprehensive treatise on HIV disease available. 

Several other chapters likewise reflect the rapid pace of advancement in the field of immune-related diseases and their treatment. In this regard, Chapter 372e, “Introduction to the Immune System,” serves as a mini-textbook of immunology for use in immunology courses. In addition, a new chapter on IgG4-mediated disease summarizes an important and newly recognized constellation of entities. 

Readers will find expanded coverage of the neurodegenerative diseases, highlighting advances in their classification and management and delineating the new understanding of mechanisms responsible for the deposition and spread of pathogenic protein aggregates in these disorders. The chapter on chronic hepatitis discusses in detail the dramatic new discoveries in the use of direct-acting antiviral agents for the treatment of hepatitis C virus disease; these agents are responsible for some of the most exciting therapeutic advances in medicine today. 

The rapidly expanding application of genetic knowledge to medicine is covered in many chapters, including a new chapter on microbial genomics and infectious diseases and substantially updated chapters on the human microbiome and chromosomal genetic disorders. Other new chapters address timely topics such as the impact of climate change on disease, infections in U.S. veterans returning from foreign wars, and advances in contraception and the treatment of infertility. Another topic of increasing interest, the impact of aging on health and disease, is addressed by several chapters, including a newly authored chapter on the biology of aging. A new chapter on men’s health complements the updated chapter on women’s health. New chapters also address diverse topics including the emerging field of tissue engineering, the examination of the comatose patient, the management of heart failure, the major characteristics of helminths and helminthic infections, specific cardiac valvular disorders, venous and lymphatic diseases of the extremities, renovascular disease, late complications of diabetes, chronic myeloid leukemia, heat-related illnesses, fatigue, polyglandular failure syndromes, and nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. 

Supplementing new content and updates on diseases and patient care, new videos in this edition cover sleep disorders, tissue engineering, noninvasive cardiac imaging, examination of the comatose patient, and myasthenia gravis and other diseases of the neuromuscular junction. New atlases for this edition address noninvasive imaging, percutaneous revascularization, and gastrointestinal endoscopy. 

We have many people to thank for their efforts in producing this book. First, the authors have done a superb job of producing authoritative chapters that synthesize vast amounts of scientific and clinical data to create state-of-the-art descriptions of medical disorders encompassed by internal medicine. In today’s information-rich, rapidly evolving environment, they have ensured that this information is current. Helpful suggestions and critical input have been provided by a number of colleagues; particularly notable was the advice of Chung Owyang on the Gastroenterology Section. We are most grateful to our colleagues in each of our editorial offices who have kept track of the work in its various phases and facilitated communication with the authors, with the McGraw-Hill Education staff, and among the editors: Patricia Conrad, Patricia L. Duffey, Gregory K. Folkers, Julie B. McCoy, Elizabeth Robbins, Anita Rodriguez, and Stephanie Tribuna. 

The staff at McGraw-Hill Education has been a constant source of support and expertise. James Shanahan, Associate Publisher for McGraw-Hill Education’s Professional Publishing Division, has been a superb and insightful partner to the editors, guiding the development of the book and its related products in new formats. Kim Davis, as Associate Managing Editor, has adeptly ensured that the complex production of this multi-authored textbook proceeded smoothly and efficiently. Dominik Pucek oversaw the production of the new procedural videos. Jeffrey Herzich ably served as production manager for this new edition. 

We are privileged to have compiled this 19th edition and are enthusiastic about all that it offers our readers. We learned much in the process of editing Harrison’s and hope that you will find this edition a uniquely valuable educational resource. 

The Editors 

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